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Claude M Wischik Selected Research

hydromethylthionine

4/2022HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine.
1/2022Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine.
1/2022Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine.
1/2021Proteomic Analysis of Hydromethylthionine in the Line 66 Model of Frontotemporal Dementia Demonstrates Actions on Tau-Dependent and Tau-Independent Networks.
1/2021Long-Term Hydromethylthionine Treatment Is Associated with Delayed Clinical Onset and Slowing of Cerebral Atrophy in a Pre-Symptomatic P301S MAPT Mutation Carrier.
1/2020Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia.
1/2019Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer's Disease.
10/2018Cysteine-Independent Inhibition of Alzheimer's Disease-like Paired Helical Filament Assembly by Leuco-Methylthioninium (LMT).
1/2018Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer's Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial.
1/2017A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy.

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Claude M Wischik Research Topics

Disease

27Alzheimer Disease (Alzheimer's Disease)
04/2022 - 11/2008
5Atrophy
04/2022 - 01/2018
5Parkinson Disease (Parkinson's Disease)
01/2022 - 01/2017
4Tauopathies
04/2022 - 04/2015
4Frontotemporal Dementia (Semantic Dementia)
01/2021 - 01/2020
3Cognitive Dysfunction
04/2022 - 01/2009
3Neurodegenerative Diseases (Neurodegenerative Disease)
01/2022 - 01/2017
3Synucleinopathies
01/2022 - 01/2017
3Dementia (Dementias)
01/2022 - 12/2009
1Amyloidosis
01/2022
1Mitochondrial Diseases (Mitochondrial Disease)
01/2021
1Disease Progression
11/2020
1Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)
01/2020
1Neuroblastoma
01/2019
1Motor Disorders
01/2019
1Neurobehavioral Manifestations
01/2017

Drug/Important Bio-Agent (IBA)

14tau Proteins (tau Protein)IBA
04/2022 - 01/2015
10hydromethylthionineIBA
04/2022 - 01/2017
5Proteins (Proteins, Gene)FDA Link
01/2021 - 12/2009
3Amyloid (Amyloid Fibrils)IBA
01/2022 - 06/2015
3alpha-SynucleinIBA
01/2022 - 12/2009
3SynucleinsIBA
01/2021 - 01/2017
3Pharmaceutical PreparationsIBA
01/2020 - 09/2011
2Cholinergic Agents (Cholinergics)IBA
01/2020 - 01/2009
1Rivastigmine (Exelon)FDA LinkGeneric
04/2022
1Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
04/2022
1Mesylates (Mesylate)IBA
01/2022
1MetalsIBA
01/2021
1Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
01/2021
1MCOIBA
01/2021
1Biomarkers (Surrogate Marker)IBA
11/2020
1Biological ProductsIBA
11/2020
1Cholinesterase Inhibitors (Anticholinesterases)IBA
01/2020
1Memantine (Namenda)FDA Link
01/2020
1Cysteine (L-Cysteine)FDA Link
10/2018
1PrionsIBA
01/2018
1Glucose (Dextrose)FDA LinkGeneric
01/2018
1DisulfidesIBA
11/2017
1Methylene Blue (Methylthioninium Chloride)FDA Link
12/2016
1hexamethylpropyleneamine oximeIBA
09/2011
1Qa-SNARE Proteins (Syntaxin)IBA
12/2009
1SNARE Proteins (SNAREs)IBA
12/2009
1thiazin redIBA
11/2008
1Amyloid beta-PeptidesIBA
11/2008
1Coloring Agents (Dyes)IBA
11/2008

Therapy/Procedure

9Therapeutics
04/2022 - 04/2014
2Activities of Daily Living (ADL)
01/2018 - 12/2016